InterPro Entry IPR001171

## Ergosterol biosynthesis ERG4/ERG24 enzymes

Database | InterPro
Accession | IPR001171; ERG4_ERG24 (matches 29 proteins)
Name | Ergosterol biosynthesis ERG4/ERG24 enzymes
Type | Family
Dates | 08-OCT-1999 (created) 14-NOV-2000 (last modified)
Signatures | PS01017; ERG4_ERG24_1 (16 proteins) PS01018; ERG4_ERG24_2 (13 proteins) PF01222; ERG4_ERG24 (29 proteins)
Component | membrane (GO:0016020)

Abstract

The two fungal enzymes, C-14 sterol reductase (gene ERG24 in budding yeast and erg3 in Neurospora Crassa) and C-24(28) sterol reductase (gene ERG4 in budding yeast and sts1 in fission yeast), are involved in ergosterol biosynthesis. They act by reducing double bonds in precursors of ergosterol [1]. These proteins are highly hydrophobic and seem to contain seven or eight transmembrane regions. Chicken lamin B receptor that is thought to anchor the lamina to the inner nuclear membrane belongs to this family.

Examples

- P38670 ER24_NEUCR
- P23913 LBR_CHICK
- P36209 STS1_SCHPO
View examples

References

1. Lai M.H., Bard M., Pierson C.A., Alexander J.F., Goebl M., Carter G.T., Kirsch D.R.
   The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway.
   Gene 140: 41-49(1994). [MEDLINE:94171077] [PUB00001844]

Database links | PROSITE doc; PDOC00780 Blocks; IPB001171
Matches | Table all Graphical all Condensed graphical view