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Click to Display mRNA-Genomic Alignments (spanning 2391 bps)

| Homo sapiens Official Gene Symbol and Name (HGNC)

| SCYB11: small inducible cytokine subfamily B (Cys-X-Cys), member 11
| LocusID: 6373

Overview | ?

RefSeq Summary: Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. Small inducible cytokine subfamily B member 11 (SCYB11) is a CXC member of the chemokine superfamily. It induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding SCYB11 protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of SCYB11 gene transcription.

| Proteome Summary: Cytokine B11; CXC chemokine that has chemotactic activity on activated T cells
| Locus Type: | gene with protein product, function known or inferred
| Product: | small inducible cytokine subfamily B (Cys-X-Cys), member 11 precursor
| Alternate Symbols: | IP9, B-R1, H174, IP-9, I-TAC, CXCL11, SCYB9B
| Alias: | small inducible cytokine subfamily B (Cys-X-Cys), member 9B

Function | Submit GeneRIF | (All Pubs) | ?

| GeneRIF: Gene References into Function:

11559369

- chemotactic activity for CXCR3-expressing cells; substrate for dipeptidylpeptidase IV

| Gene OntologyTM:
| Term | Evidence | Source | Pub

- chemokine

E

Proteome

pm

- chemotaxis

E

Proteome

pm

- signal transduction

P

Proteome

pm

- cell-cell signalling

E

Proteome

pm

- inflammatory response

P

Proteome

pm

- response to pathogenic fungi

P

Proteome

pm

| Other Ontologies:
| Term | Evidence | Source | Pub

- Response to injury

NR

Proteome

pm

- Anti-pathogen response

NR

Proteome

pm

- Cell migration/motility

NR

Proteome

pm

- Cell-to-cell signalling

NR

Proteome

pm

Relationships | ?

| Mouse Homology Maps: |  |  |  |
| NCBI vs. MGD |  |  | Scyb11 | Hs
| UCSC vs. MGD |  |  | Scyb11 | Hs

Map Information | ?

| Chromosome: | 4 |  |  | mv
| Cytogenetic: | 4q21.2 |  | RefSeq |

NCBI Reference Sequences (RefSeq) | ?

Category: REVIEWED

| mRNA: | NM_005409 |  |
| Protein: | NP_005400 small inducible cytokine subfamily B (Cys-X-Cys), member 11 precursor | BL
| Domains: | Small cytokines (intecrine/chemokine) | score: 76 |
|  | Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). | score: 88 |
| GenBank Source: | AF030514,U66096,Y15220 |  |

Category: NCBI Genome Annotation

| Genomic Contig: | NT_022760 |  | gb sv mv ev mm
| Annotated transcripts/proteins for this locus:
--- | ---
| Evidence: | supported by alignment with mRNA |  |
| Model mRNA: | XM_113426 |  |
| Model Protein: | XP_113426 |  | BL
| Domains: | Small cytokines (intecrine/chemokine), interleukin-8 like | score: 87 |
|  | Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). | score: 89 |

GenBank Sequences | ?

| Nucleotide | Type | Protein |  |
| A82120 | g | CAB69205 |  | BL
| AF053972 | g | AAD10206 |  | BL
| AF077867 | g | AAD38327 |  | BL
| Y15221 | g | CAB51859 |  | BL
| AF002985 | m | AAC51845 |  | BL
| AF030514 | m | AAC39775 |  | BL
| BC005292 | m | AAH05292 |  | BL
| U59286 | m | AAB17374 |  | BL
| U66096 | m | AAD38867 |  | BL
| Y15220 | m | CAA75510 |  | BL

Additional Links | ?

- OMIM: 604852

- UniGene: Hs.103982

- GeneCards

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