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Click to Display mRNA-Genomic Alignments (spanning 81484 bps)

| Mus musculus Official Gene Symbol and Name (MGI)

| Kit: kit oncogene
| LocusID: 16590

Overview | ?

| RefSeq Summary: The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor.
| Locus Type: | gene with protein product, function known or inferred
| Product: | c-kit
| Alternate Symbols: | W, Bs, Fdc, Ssm, CD117, c-KIT, belly-spot
| Alias: | dominant spotting spotted sterile male Steel Factor Receptor Dominant white spotting c-kit proto-oncogene protein

Function | Submit GeneRIF | (All Pubs) | ?

| GeneRIF: Gene References into Function:

11964302

- Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis

| Gene OntologyTM:
| Term | Evidence | Source | Pub

- membrane

IEA

MGD

- ATP binding

IEA

MGD

- transferase

IEA

MGD

- intracellular

IEA

MGD

- protein kinase

IEA

MGD

- protein tyrosine kinase

IEA

MGD

- regulation of cell cycle

IEA

MGD

- integral membrane protein

IEA

MGD

- cell growth and/or maintenance

IEA

MGD

- protein amino acid phosphorylation

IEA

MGD

- transmembrane receptor protein tyrosine kinase

IEA

MGD

- transmembrane receptor protein tyrosine kinase signaling pathway

IEA

MGD

Relationships | ?

| Human Homology Maps: |  |  |  |
| NCBI vs. MGD |  | 4q11-q12 | KIT | Mm Hs
| UCSC vs. MGD |  | 4q11-q12 | KIT | Mm Hs
| NCBI vs. EST-based RH Map |  | 4q11-q12 | X06182 | Mm Hs
| UCSC vs. EST-based RH Map |  | 4q11-q12 | X06182 | Mm Hs
| UCSC vs. Hudson et al. |  | 4q11-q12 | AW263947 | Mm Hs

Map Information | ?

| Chromosome: | 5 |  |  | mv
| Cytogenetic: | 5 |  | RefSeq |
| Genetic: | 5 42.0 cM |  | MGD |
| Markers: | Chr. 5 | 3714 |  |
|  | Chr. 5 | Y00864 |  |

NCBI Reference Sequences (RefSeq) | ?

Category: REVIEWED

| mRNA: | NM_021099 |  |
| Protein: | NP_066922 c-kit | BL
| Domains: | Immunoglobulin | score: 125 |
|  | Immunoglobulin domain | score: 94 |
|  | Protein kinase domain | score: 198 |
|  | Immunoglobulin C-2 Type | score: 83 |
|  | Tyrosine kinase, catalytic domain | score: 610 |
|  | Serine/Threonine protein kinases, catalytic domain | score: 159 |
| Strain | BALB/c |  |
| GenBank Source: | AW741410,Y00864 |  |

Category: NCBI Genome Annotation

| Genomic Contig: | NW_000230 |  | gb sv mv ev mm
| Strain | C57BL/6J |  |
| Annotated transcripts/proteins for this locus:
--- | ---
| Evidence: | supported by alignment with both mRNA and ESTs (51) |  |
| Model mRNA: | XM_132123 |  |
| Model Protein: | XP_132123 |  | BL
| Domains: | Immunoglobulin | score: 125 |
|  | Immunoglobulin domain | score: 94 |
|  | Protein kinase domain | score: 402 |
|  | Immunoglobulin C-2 Type | score: 83 |
|  | Tyrosine kinase, catalytic domain | score: 616 |
|  | Serine/Threonine protein kinases, catalytic domain | score: 308 |

GenBank Sequences | ?

| Nucleotide | Type | Protein | Strain |
| L11358 | g | AAA37420 | BALB/c | BL
| X65998 | g | CAA46799 | ICR | BL
|  |  | CAA46800 |  | BL
| AW741410 | m |  |  |
| X65997 | m | CAA46798 | ICR | BL
| Y00864 | m | CAA68772 | BALB/c | BL

Additional Links | ?

- UniGene: Mm.4394

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