## CD:

## pfam00035

##

Description: | dsrm, Double-stranded RNA binding motif. Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localization of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA.
CD status: | Full-length sequences, including 3D structure if known. Alignment from source, reindexed to representative
Source: | Pfam[US], Pfam[UK]
Created: | 12-Sep-2001
References: | PubMed

Taxonomy spanned:

root ->

[ 81] from | cellular organisms
[ 7] from | Viruses

Aligned sequences: | 89
Representative: | Consensus sequence:
Aligned range: | 1-67

Sequence:

    PKSALQELAQKRKLPLPEYELVEEEGPAHAPRFTVEVTVGGKTYFEGSGSSKKEAKQNAA
    EAALRIL

This CD alignment includes 3D structure. To display structure, download Cn3D v3.0! showing

Aligned chains All chains Virtual Bonds All Atoms |  | Launch Cn3D HTML Display Text Display | FASTA with gaps Phylip format See ASN.1 file | Conservation color threshold: Alignment width:

pick aligned sequences (will be added to selection above)
| 3D | PDB-Id/gi | Definition
--- | --- | --- | ---
|  | 1DI2 A | Xenopus laevis [CD]
|  | 1QU6 A | Homo sapiens [CD]
|  | 1EKZ A | Drosophila melanogaster [CD]
| 7531276 | RIBONUCLEASE III (RNASE III) [CD]
| 7531197 | RIBONUCLEASE III (RNASE III) [CD]
| 1710609 | RIBONUCLEASE III (RNASE III) [CD]
| 7531189 | RIBONUCLEASE III (RNASE III) [CD]
| 7531188 | RIBONUCLEASE III (RNASE III) [CD]
| 7531275 | RIBONUCLEASE III (RNASE III) [CD]
| 2500554 | RIBONUCLEASE III (RNASE III) [CD]
| 6094109 | RIBONUCLEASE III (RNASE III) [CD]
| 2500555 | HYPOTHETICAL 27.1 KDA PROTEIN SLR0346 [CD]
| 2160163 | Sequence of BAC F21M12 from Arabidopsis thaliana chromosome 1 [CD]
| 2160163 | Sequence of BAC F21M12 from Arabidopsis thaliana chromosome 1 [CD]
| 1710608 | RIBONUCLEASE III (RNASE III) [CD]
| 1173093 | RIBONUCLEASE III (RNASE III) [CD]
| 133151 | RIBONUCLEASE III (RNASE III) [CD]
| 7531196 | RIBONUCLEASE III (RNASE III) [CD]
| 7531190 | RIBONUCLEASE III (RNASE III) [CD]
| 2500552 | RIBONUCLEASE III (RNASE III) [CD]
| 6226018 | RIBONUCLEASE III (RNASE III) [CD]
| 2500558 | PUTATIVE RIBONUCLEASE III (RNASE III) [CD]
| 7531193 | RIBONUCLEASE III (RNASE III) [CD]
| 7531191 | RIBONUCLEASE III (RNASE III) [CD]
| 2500556 | PUTTIVE PROTEIN A464R [CD]
| 2500553 | RIBONUCLEASE III (RNASE III) [CD]
| 3850247 | Coltivirus JKT-7075 segment 8 Vp8 gene, complete cds [CD]
| 458490 | Caenorhabditis elegans chromosome III clone T20G5 [CD]
| 458490 | Caenorhabditis elegans chromosome III clone T20G5 [CD]
| 3334379 | TAR RNA-BINDING PROTEIN 2 (PROTAMINE-1 RNA BINDING PROTEIN) (PRM-1 RNA BINDING PROTEIN) [CD]
| 3334379 | TAR RNA-BINDING PROTEIN 2 (PROTAMINE-1 RNA BINDING PROTEIN) (PRM-1 RNA BINDING PROTEIN) [CD]
| 3290198 | Homo sapiens [CD]
| 3290198 | Homo sapiens [CD]
| 3290198 | Homo sapiens [CD]
| 3334381 | DOUBLE STRANDED RNA BINDING PROTEIN A (XLRBPA) [CD]
| 9789804 | DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG [CD]
| 9789804 | DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG [CD]
| 1519659 | Caenorhabditis elegans chromosome X clone F55A4 strain Bristol N2 [CD]
| 1519659 | Caenorhabditis elegans chromosome X clone F55A4 strain Bristol N2 [CD]
| 1519663 | Caenorhabditis elegans chromosome X clone F55A4 strain Bristol N2 [CD]
| 1519663 | Caenorhabditis elegans chromosome X clone F55A4 strain Bristol N2 [CD]
| 1519663 | Caenorhabditis elegans chromosome X clone F55A4 strain Bristol N2 [CD]
| 1519663 | Caenorhabditis elegans chromosome X clone F55A4 strain Bristol N2 [CD]
| 134950 | MATERNAL EFFECT PROTEIN STAUFEN [CD]
| 134950 | MATERNAL EFFECT PROTEIN STAUFEN [CD]
| 134950 | MATERNAL EFFECT PROTEIN STAUFEN [CD]
| 134950 | MATERNAL EFFECT PROTEIN STAUFEN [CD]
| 532315 | NF90 protein [CD]
| 532315 | NF90 protein [CD]
| 2829669 | DOUBLE-STRANDED RNA-SPECIFIC EDITASE 1 (DSRNA ADENOSINE DEAMINASE) (RNA EDITING ENZYME 1) [CD]
| 2829669 | DOUBLE-STRANDED RNA-SPECIFIC EDITASE 1 (DSRNA ADENOSINE DEAMINASE) (RNA EDITING ENZYME 1) [CD]
| 1814270 | Rattus norvegicus double-stranded RNA specific adenosine deaminase (RED2) mRNA, and translated products [CD]
| 1814270 | Rattus norvegicus double-stranded RNA specific adenosine deaminase (RED2) mRNA, and translated products [CD]
| 7290203 | Drosophila melanogaster chromosome X [CD]
| 7290203 | Drosophila melanogaster chromosome X [CD]
| 125527 | INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (INTERFERON-INDUCIBLE RNA-DEPENDENT PROTEIN KINASE) (P68 KINASE) (P1/EIF-2A PROTEIN KINASE) [CD]
| 2507204 | INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (INTERFERON-INDUCIBLE RNA-DEPENDENT PROTEIN KINASE) (P68 KINASE) (P1/EIF-2A PROTEIN KINASE) (SERINE/THREONINE-PROTEIN KINASE TIK) [CD]
| 2507204 | INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (INTERFERON-INDUCIBLE RNA-DEPENDENT PROTEIN KINASE) (P68 KINASE) (P1/EIF-2A PROTEIN KINASE) (SERINE/THREONINE-PROTEIN KINASE TIK) [CD]
| 468373 | RNA-dependent initiation factor-2 kinase [CD]
| 465071 | PROTEIN E3 [CD]
| 2984731 | Orf virus interferon resistance determinant protein (OV20.0L) gene, complete cds; and RNA polymerase subunit homolog (OV20.3L) gene, partial cds [CD]
| 673456 | M.musculus Tenr mRNA for RNA binding protein, and translated products [CD]
| 1706532 | DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE (DRADA) (136 KDA DOUBLE-STRANDED RNA BINDING PROTEIN) (P136) (K88DSRBP) [CD]
| 1706532 | DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE (DRADA) (136 KDA DOUBLE-STRANDED RNA BINDING PROTEIN) (P136) (K88DSRBP) [CD]
| 1706532 | DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE (DRADA) (136 KDA DOUBLE-STRANDED RNA BINDING PROTEIN) (P136) (K88DSRBP) [CD]
| 1932813 | Xenopus laevis dsRNA adenosine deaminase (dsRAD-1) mRNA, and translated products [CD]
| 1932813 | Xenopus laevis dsRNA adenosine deaminase (dsRAD-1) mRNA, and translated products [CD]
| 586013 | SON PROTEIN (SON3) [CD]
| 465898 | HYPOTHETICAL HELICASE K12H4.8 IN CHROMOSOME III [CD]
| 4490937 | Homo sapiens mRNA for hypothetical helicase K12H4.8-like protein, partial, and translated products [CD]
| 2500557 | RIBONUCLEASE III (RNASE III) [CD]
| 1350789 | 60S RIBOSOMAL PROTEIN L3, MITOCHONDRIAL PRECURSOR (YML3) [CD]
| 2668620 | Acyrthosiphon pisum virus protein P1 gene, complete cds; and protein P2 gene, partial cds [CD]
| 3850201 | Coltivirus JKT-6423 vp12 gene, complete cds [CD]
| 129540 | DOUBLE-STRAND-SPECIFIC PAC1 RIBONUCLEASE (HCS PROTEIN) [CD]
| 2388673 | Drosophila C virus strain EB, complete genome [CD]
| 3913434 | ATP-DEPENDENT RNA HELICASE A (NUCLEAR DNA HELICASE II) (NDH II) (DEAD-BOX PROTEIN 9) (MHEL-5) [CD]
| 3913434 | ATP-DEPENDENT RNA HELICASE A (NUCLEAR DNA HELICASE II) (NDH II) (DEAD-BOX PROTEIN 9) (MHEL-5) [CD]
| 3650397 | Sciara ocellaris [CD]
| 3650397 | Sciara ocellaris [CD]
| 127156 | DOSAGE COMPENSATION REGULATOR (MALE-LESS PROTEIN) (NO ACTION POTENTIAL PROTEIN) [CD]
| 127156 | DOSAGE COMPENSATION REGULATOR (MALE-LESS PROTEIN) (NO ACTION POTENTIAL PROTEIN) [CD]
| 3913436 | PROBABLE ATP-DEPENDENT RNA HELICASE A (NUCLEAR DNA HELICASE II) (NDH II) [CD]
| 3913436 | PROBABLE ATP-DEPENDENT RNA HELICASE A (NUCLEAR DNA HELICASE II) (NDH II) [CD]
| 466149 | HYPOTHETICAL 80.5 KD PROTEIN ZK632.2 IN CHROMOSOME III [CD]
| 3283023 | Caenorhabditis elegans putative RNA adenosine deaminase mRNA, complete cds [CD]
| 12643664 | DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG [CD]
| 3334380 | TAR RNA-BINDING PROTEIN 2 (TRANS-ACTIVATION RESPONSIVE RNA-BINDING PROTEIN) [CD]

for