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Click to Display mRNA-Genomic Alignments (spanning 110510 bps)

| Homo sapiens Official Gene Symbol and Name (HGNC)

| PTPRM: protein tyrosine phosphatase, receptor type, M
| LocusID: 5797

Overview | ?

RefSeq Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion.

| Proteome Summary: Receptor-type protein tyrosine phosphatase M
| Locus Type: | gene with protein product, function known or inferred
| Product: | protein tyrosine phosphatase, receptor type, M precursor
| Alternate Symbols: | RPTPM, RPTPU, PTPRL1, HR-PTPU, R-PTP-MU
| Alias: | protein tyrosine phosphatase mu precursor protein tyrosine phosphatase, receptor type, mu polypeptide

Function | Submit GeneRIF | (All Pubs) | ?

| EC Number: 3.1.3.48

| Gene OntologyTM:
| Term | Evidence | Source | Pub

- protein dephosphorylation

E

Proteome

pm

- integral plasma membrane protein

P

Proteome

pm

- transmembrane receptor protein tyrosine phosphatase

E

Proteome

pm

| Other Ontologies:
| Term | Evidence | Source | Pub

- Hydrolase

E

Proteome

pm

- Integral membrane

P

Proteome

pm

- Receptor (signalling)

P

Proteome

pm

Relationships | ?

| Mouse Homology Maps: |  |  |  |
| NCBI vs. MGD |  | 17 38.30 cM | Ptprm | Hs Mm
| UCSC vs. MGD |  | 17 38.30 cM | Ptprm | Hs Mm

Map Information | ?

| Chromosome: | 18 |  |  | mv
| Cytogenetic: | 18p11.2 |  | HUGO |
| Markers: | Chr. - | G10607 |  |
|  | Chr. 18 | WI-9017 |  | mv
|  | Chr. 18 | Cda09f01 |  | mv

NCBI Reference Sequences (RefSeq) | ?

Category: REVIEWED

| mRNA: | NM_002845 |  |
| Protein: | NP_002836 protein tyrosine phosphatase, receptor type, M precursor | BL
| Domains: | MAM domain | score: 406 |
|  | Immunoglobulin | score: 102 |
|  | Fibronectin type 3 domain | score: 101 |
|  | Fibronectin type III domain | score: 126 |
|  | Protein-tyrosine phosphatase | score: 800 |
|  | Dual specificity phosphatase, catalytic domain | score: 86 |
|  | Dual specificity phosphatase, catalytic domain | score: 84 |
|  | Protein tyrosine phosphatase, catalytic domain | score: 857 |
|  | Protein tyrosine phosphatase, catalytic domain motif | score: 324 |
|  | Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) | score: 436 |
| GenBank Source: | AA281524,X58288 |  |

Category: NCBI Genome Annotation

| Genomic Contig: | NT_030853 |  | gb sv mv ev mm
| Annotated transcripts/proteins for this locus:
--- | ---
| Evidence: | supported by alignment with both mRNA and ESTs (15) |  |
| Model mRNA: | XM_012741 |  |
| Model Protein: | XP_012741 |  | BL
| Domains: | Protein-tyrosine phosphatase | score: 766 |
|  | Dual specificity phosphatase, catalytic domain | score: 84 |
|  | Protein tyrosine phosphatase, catalytic domain | score: 786 |
|  | Protein tyrosine phosphatase, catalytic domain motif | score: 310 |

GenBank Sequences | ?

| Nucleotide | Type | Protein |  |
| AA281524 | m |  |  |
| X58288 | m | CAA41226 |  | BL

Additional Links | ?

- OMIM: 176888

- UniGene: Hs.154151

- GeneCards

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