InterPro Entry IPR001064

## Crystallin

Database | InterPro
Accession | IPR001064; Crystallin (matches 132 proteins)
Name | Crystallin
Type | Domain
Dates | 08-OCT-1999 (created) 05-DEC-2000 (last modified)
Signatures | PS00225; CRYSTALLIN_BETAGAMMA (1586 proteins) PR01367; BGCRYSTALLIN (102 proteins) PF00030; crystall (113 proteins) SM00247; XTALbg (129 proteins)

Abstract

Crystallins are the dominant structural components of the eye lens. Among the different type of crystallins, the beta and gamma crystallins form a family of related proteins [1, 2]. Structurally, beta and gamma crystallins are composed of two similar domains which, in turn, are each composed of two similar motifs with the two domains connected by a short connecting peptide. Each motif, which is about forty amino acid residues long, is folded in a distinctive 'Greek key' pattern.

Examples

- P02966 DESS_MYXXA: A calcium-binding protein from the sporulating bacterium Myxococcus xanthusa forms a major part of the spore coat
- P46058 EDSP_CYNPY
- P09353 SR3A_PHYPO: Spherulin 3a from the slime mold Physarum polycephalum. Spherulin 3a is a development specific protein synthesized in response to various kinds of stress leading to encystment and dormancy. The sequence of Spherulin 3a consists of two 'Greek key' motifs [3]
- P06504 CRBS_BOVIN
- Q91314 CB12_RANCA
- P07317 CRBA_RANTE
View examples

References

1. Wistow G.J., Piatigorsky J.
   Lens crystallins: the evolution and expression of proteins for a highly specialized tissue.
   Annu. Rev. Biochem. 57: 479-504(1988). [MEDLINE:89024580] [PUB00000056]
2. Lubsen N.H., Aarts H.J.M., Schoenmakers J.G.G.
   The evolution of lenticular proteins: the beta- and gamma-crystallin super gene family.
   Prog. Biophys. Mol. Biol. 51: 47-76(1988). [MEDLINE:89113769] [PUB00004933]
3. Wistow G.
   Evolution of a protein superfamily: relationships between vertebrate lens crystallins and microorganism dormancy proteins.
   J. Mol. Evol. 30: 140-145(1990). [MEDLINE:90189184] [PUB00003409]

Database links | PROSITE doc; PDOC00197 Blocks; IPB001064
Matches | Table all Graphical all Condensed graphical view