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    ENTRY       EC 3.5.4.4
    NAME        Adenosine deaminase
    CLASS       Hydrolases
                Acting on carbon-nitrogen bonds, other than peptide bonds
                In cyclic amidines
    SYSNAME     Adenosine aminohydrolase
    REACTION    Adenosine + H2O = Inosine + NH3
    SUBSTRATE   Adenosine
                H2O
    PRODUCT     Inosine
                NH3
    INHIBITOR   Nebularine
                6-Hydroxyl-1,6-dihydropurine ribonucleoside
    COMMENT     Inhibited by Nebularine and 6-hydroxyl-1,6-dihydropurine
                ribonucleoside (Science (1989) 243, 1591-1593).
    PATHWAY     PATH: MAP00230  Purine metabolism
    DISEASE     MIM: 102700  Adenosine deaminase; Severe combined immunodeficiency
                             due to ADA deficiency (3); Hemolytic anemia due to ADA
                             excess (1)
    MOTIF       PS: PS00485  S-[LIVM]-[NS]-T-D-D-P
    GENES       ECO: ECOLI_1582(add)
                SCE: YNL141W(N1208)
                HSA: 119649(ADA)
    DBLINKS     University of Geneva ENZYME DATA BANK: 3.5.4.4
                WIT (What Is There) Metabolic Reconstruction: 3.5.4.4
                SCOP (Structural Classificaion of Proteins): 3.5.4.4
                PDB: 1ADD    1FKW    1FKX    2ADA
                PIR: DUMSA   DUHUA   A37943
    ///